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زیست شناسی::
اسیدهای صفراوی
The removal (A) DNA synthesis or injury of the liver is sensed through the bloodstream: some liver-specific factors are lost while others (such as bile acids and gut lipopolysaccharides) increase.
Huang and colleagues (2006) have proposed that these factors are bile acids that are secreted by the liver and positively regulate hepatocyte growth.
Partial hepatectomy stimulates the release of bile acids into the blood.
These bile acids are received by the hepatocytes and activate the Fxr transcription factor, which promotes cell division.
Therefore, bile acids (a relatively small percentage of the products secreted by the liver) appear to regulate the size of the liver, keeping it at a particular volume of cells.
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